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Biomarker Predicts Which Stage II Colon Cancer Patients May Benefit from Chemotherapy

Source:

CUMC Newsroom

A biomarker has been identified by a multicenter research team that predicts which stage II colon cancer patients may benefit from chemotherapy after surgery to prevent a recurrence of their disease.

Topic

Cancer
Potent and Reversible Lentiviral Vector Restriction in Murine Induced Pluripotent Stem Cells

Source:

Retrovirology

This paper characterizes the block to infection of mouse induced pluripotent stem cells (iPSC) by HIV vectors. The findings are relevant to gene therapy approaches targeting these cells.
Differential Control of Retrovirus Silencing in Embryonic Cells by Proteasomal Regulation of the ZFP809 Retroviral Repressor

Source:

Proceedings of the National Academy of Sciences

This paper probes the mechanisms by which embryonic stem cells regulate the levels of ZFP809, the major repressor of murine leukemia virus gene expression.
CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons

Source:

Molecular Cell

A new CRISPR-dependent approach to inactivate genes by inducing STOP codons by generating knockout alleles in stem cells without formation of potentially toxic DNA double-strand breaks.