Spring 2024 Stem Cells, Genome Engineering and Regenerative Medicine Course

January 4, 2024

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Spring 2024 Syllabus

Time: Tuesdays 9:00 – 11:00 AM

Location: Hammer Health Sciences LL205

Zoom / Meeting ID: 998 7032 4800 / Passcode: Cas12f

Course Director: Stephen Tsang, MD, PhD (sht2@cumc.columbia.edu)

Teaching Assistants: Hannah Hu (hh2908@columbia.edu), Anders Knudsen (ask2293@columbia.edu)

 

Description:

The lectures will include general lectures on stem cell biology followed by student presentations and discussion of the primary literature. The themes to be presented include:

  1. Genome Engineering with CRISPR, TALEN and ZFN in stem cells
  2. Basic stem cell concepts
  3. Basic cell and molecular biological characterization of endogenous stem cell populations
  4. Concepts related to reprogramming
  5. Directed differentiation of stem cell populations
  6. The use of stem cells in disease modeling or tissue replacement/repair
  7. Stem cells in regenerative medicine
  8. Current Therapies for Alzheimer’s disease, various Retinopathies and other diseases

Date

Lecturer

Title/University

Topic (TBD)

1/16/24

Emmanuelle Passegué

Alumni Professor of Genetics and Development (in Rehabilitation and Regenerative Medicine) at Columbia University; Director of Columbia Stem Cell Institute

Endogenous Stem Cell Populations / HSCs / Stem Cell Aging

1/23/24

Ron McKay (Zoom)

Founder, Lieber Institute for Brain Development, Johns Hopkins & President emeritus, ISSCR

Stem cells and the development of the nervous system

1/30/24

Andrew Anzalone (Zoom)

Scientific Co-founder at Prime Medicine, Inc

Prime Editing and beyond

2/6/24

Katherine High

President of Therapeutics at Asklepios BioPharmaceuticals; Co-founder at Spark Therapeutics; Visiting Professor at the Rockefeller University

Adeno-Associated Viral (AAV)-Mediated Gene Therapy

2/13/24

Aaron Viny

Assistant Professor of Medicine at Columbia University Irving Medical Center

3-Dimensional Genomic Techniques to Uncover the Genetic and Epigenetic Underpinnings of Diseases

2/20/24

Kapil Bharti (Zoom)

Senior Investigator,

Ocular and Stem Cell Translational Research Section, National Eye Institute, NIH

3D culture of Stem Cells/organoids

2/27/24

George Church (Zoom)

Founding Core Faculty & Lead, Synthetic Biology, Wyss Institute at Harvard University; Robert Winthrop Professor of Genetics, Harvard Medical School; Professor of Health Sciences and Technology, Harvard and MIT

Applications In Regenerative Medicine and Bio-Production of Chemicals

3/5/24

Rudolf Jaenisch (Zoom)

Professor of Biology; Core Member, Whitehead Institute; Member, Institute of Medicine

The Use of Pluripotent Cells in the Study of Genetic and Epigenetic Basis of Human Diseases

3/12/2024

SPRING BREAK