Passegué Lab
![](https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_200_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=OgZeRaa4 200w, https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_260_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=0-9uenRH 260w, https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_320_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=R9zoOK8e 320w, https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_400_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=BeHsaaTj 400w, https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_520_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=NB6PzG3D 520w, https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_640_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=hm9Bq9Rr 640w, https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_800_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=-dk91wQ4 800w, https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_1040_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=LjSLsXKg 1040w, https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_1280_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=q8iOwzVL 1280w, https://www.stemcell.columbia.edu/sites/default/files/styles/cola_media_1600_16_9/public/media/images/teaser/2024-04/passegue_xmas_party_-_lab.jpeg?itok=c6uIjSDD 1600w)
Location and Contact Information
Principal Investigator
Hematopoiesis and Hematopoietic Stem Cell Biology
Our laboratory studies how hematopoietic stem cells (HSC) regulate blood production during the lifetime of an ever-changing organism. This fundamental question is central to tissue development, maintenance and regeneration, and has implications for every aspect of adult physiology ranging from response to stress, development of diseases, and biology of aging. We are interested in identifying the mechanisms that control HSC activity in normal and a range of deregulated conditions, with the goal of identifying affected genes and pathways that could be used to develop new therapies to treat human myeloid malignancies and help combat physiological aging. Towards this end, we are employing a variety of cross-disciplinary approaches using mouse models and human samples.