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Showing 41 - 50 of 254 results.

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Source:

Journal of Clinical Investigation (JCI)

April 25, 2023

A previously uncharacterized CERT1 domain enables its homeostatic inactivation, without which sphingolipid production goes unchecked; clinical severity reflects the degree of dysregulation
Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms

April 25, 2023

RNA-binding proteins such as PUM1 regulate mRNA targets in various ways. But to understand their physiological functions we have to study their interactions as well as targets.
Collateral activity of the CRISPR/RfxCas13d system in human cells

Source:

Communications Biology

March 28, 2023

Here we show that RfxCas13d can cause collateral transcriptome destruction when targeting abundant reporter RNA and endogenous RNAs, resulting in proliferation defect in target cells.
A New Era of Hope for MDS Patients

Source:

Columbia HICCC News

March 27, 2023

Stavroula Kousteni, PhD, and Azra Raza, MD, share their ambitions as the leaders of Columbia's Edward P. Evans Center for Myelodysplastic Syndromes.
Predicting Immunotherapy Response in Head and Neck Cancer

Source:

Columbia HICCC News

March 15, 2023

We're actively exploring the complex interplay between the immune system, microenvironment and tumor to identify molecular targets for head and neck cancer, and other solid tumor treatments.
Simple, Fast, and Efficient Method for Derivation of Dermal Fibroblasts From Skin Biopsies

Source:

Current Protocols

March 13, 2023

We developed a fast and simple protocol to grow dermal fibroblasts from skin biopsies.
Noncoding translation mitigation

Source:

Nature

March 12, 2023

Here we integrate massively parallel analyses of more than 10,000 human genomic sequences and millions of random sequences with genome-wide CRISPR screens.
Christine Chio, PhD, Receives Hirschl Trust Research Award

Source:

CUIMC newsroom

March 9, 2023

Congratulations to Dr. Christine Chio, who has received a Hirschl Trust Research Award for her work studying pancreatic ductal adenocarcinoma.
Rossella Labella, PhD, Named Inaugural Walkers Scholar to Advance Myelodysplastic Syndrome Research

Source:

Columbia HICCC News

March 8, 2023

As a Walker Scholar, Dr. Labella joins a group of exceptional researchers at the Edward P. Evans Myelodysplastic Syndrome (MDS) Fellowship Program.
Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites

Source:

Science Advances

February 17, 2023

We show that CPSF6 deficiency in human patients and zebrafish causes neurological, skeletal, and cardiovascular defects by altering poly(A) site choice to modulate protein levels during development.

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