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Showing 81 - 90 of 254 results.

Bioengineering Human Cartilage–Bone Tissues for Modeling of Osteoarthritis

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Stem Cells and Development

March 14, 2022

We highlight human induced pluripotent stem cells (hiPSCs) as the advantageous cell source for these models and review approaches for chondrogenic fate specification from hiPSCs.
Chao Lu One of Two Columbia Scientists To Receive Hirschl Trust Research Awards

March 7, 2022

Chao Lu, PhD has been awarded the prestigious 2022 Hirschl Trust Research Awards by the Irma T. Hirschl Trust Research Scientist Program.
Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells

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Journal of Gastroenterology

March 4, 2022

We aimed to identify miRNAs that are upregulated during terminal differentiation in the human colon epithelium, and elucidate their role in the mechanistic control of stem cell properties.
CRISPR genome surgery in a novel humanized model for autosomal dominant retinitis pigmentosa

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Cell Press

March 1, 2022

This study demonstrates the effectiveness of AR treatment of adRP in the human genomic context while revealing the feasibility of its application for other autosomal dominant disorders.
Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome

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Nature Cardiovascular Research

February 22, 2022

Our study demonstrates that SIGMAR1 is a potential therapeutic target for Timothy syndrome and possibly other inherited arrhythmias such as LQTS1 and LQTS2.
Cough Suppressant Knocks Some Hearts Back into Rhythm

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CUMC Newsroom

February 17, 2022

An over-the-counter cough suppressant can knock some heart cells back into rhythm, a finding that may lead to a new way to treat a rare heart condition called long QT syndrome.
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease

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Brain

February 11, 2022

We show that tubulin tyrosine ligase hemizygous mice exhibit decreased tyrosinated microtubules, reduced dendritic spine density, and both synaptic plasticity and memory deficits.
Regeneration of Jaw Joint Cartilage in Adult Zebrafish

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Frontiers in Cell and Developmental Biology

January 28, 2022

We performed single-cell RNA sequencing of the uninjured adult jaw joint and identified multiple skeletal, connective tissue, and fibroblast subtypes
Michael Shen One of Five Columbia Faculty Named AAAS Fellows

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Columbia News

January 26, 2022

Columbia's 2021 AAAS Fellows are recognized for their contributions to teaching and research.
LA Times Today: How COVID changes the brain

January 19, 2022

Dr. Maura Boldrini, a neuroscientist at Columbia University, says new research could have far-reaching implications for other mental illnesses beyond COVID.

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